姓名：陆艳
职称：副研究员
电子邮箱：lueyan@fudan.edu.cn
办公地点：复旦大学江湾校区生命科学楼A309
个人简介
糖心vlog副研究员，博士生导师。2006年作为直博生进入复旦大学学习，2012年获复旦大学遗传学博士学位，随后进入中国科学院上海生命科学研究院从事研究工作，历任助理研究员、副研究员。2020年进入糖心vlog，任副研究员。长期从事群体遗传学和基因组学相关研究，近年来以第一作者或通讯作者在Nature, Cell Reports, National Science Review, Molecular Biology and Evolution, iScience, Genome Biology, Science China Life Sciences等国际权威杂志上发表多篇SCI研究性论文。入选上海市青年科技英才“扬帆计划”，主持国家自然科学基金青年项目、任国家重点研发计划课题负责人和子课题负责人，研究成果入选F1000，中国生物信息学十大科学进展、中国生物信息学十大数据库等。上海人类学学会“分子人类学”专业委员会秘书长、常务委员。
研究方向
1. “病原、媒介、宿主”的遗传多样性及共进化
2. 人群的遗传结构及适应性进化
3. 感染性疾病的遗传基础和泛基因组研究
4. 生物信息数据库和在线分析平台
招生专业
遗传学 微生物学 生物信息学
代表性论文和论著
1. Yang Gao#, Xiaofei Yang#, Hao Chen#, Xinjiang Tan#, Zhaoqing Yang#, Lian Deng#, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Xiaohan Zhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Bingyin Shi, Li Jin, Zhibin Hu, Chinese Pangenome Consortium#, Yan Lu*, Jiayou Chu*, Kai Ye*, Shuhua Xu*, A pangenome reference of 36 Chinese populations. Nature, 2023
2. Qi Liu, Bo Xie, Yang Gao, Shuhua Xu*, Yan Lu*. A protocol for applying low-coverage whole-genome sequencing data in structural variation studies, STAR Protocols, 2023
3. Qi Liu, Ke Yang, Bo Xie, Yang Gao, Shuhua Xu*, Yan Lu*. Mapping Structural Variations in Haemaphysalis longicornis and Rhipicephalus microplus Reveals Vector-Pathogen Adaptation, iScience, 2023
4. Yuwen Pan, Jia Wen, Zhilin Ning, Yuan Yuan, Xubing Liu, Yajun Yang, Yaqun Guan, Yan Lu*, Dolikun Mamatyusupu, Shuhua Xu*. Comparative genomic and transcriptomic analyses reveal the impacts of genetic admixture in Kazaks, Uyghurs, and Huis, Molecular Biology and Evolution, 2023
5. Zeshan Lin#, Yan Lu#, Guoliang Yu; Huajing Teng, Bao Wang, Yajun Yang, Qinglan Li, Zhongsheng Sun, Shuhua Xu*, Wen Wang*, Peng Tian*. Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation, SCIENCE CHINA Life Sciences, 2023
6. Fang Luo#, Wenbin Yang#, Mingbo Yin, Xiaojin Mo, Yuhong Pang, Chengsong Sun, Bingkuan Zhu, Wei Zhang, Cun Yi, Zhidan Li, Jipeng Wang, Bin Xu, Zheng Feng, Yangyi Huang, Yan Lu*, Wei Hu*. A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching, Cell Reports, 2022, 39(1)
7. Yuwen Pan#, Chao Zhang#, Yan Lu#, Zhilin Ning, Dongsheng Lu, Yang Gao, Xiaohan Zhao, Yajun Yang, Yaqun Guan, Dolikun Mamatyusupu, Shuhua Xu. Genomic diversity and post-admixture adaptation in the Uyghurs,National Science Review, 2021
8. Hao Chen#, Yan Lu#, Dongsheng Lu, Shuhua Xu*. Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data, BMC Bioinformatics, 2021.
9. Chao Zhang#, Yang Gao#, Zhilin Ning#, Yan Lu#, Xiaoxi Zhang, Jiaojiao Liu, Bo Xie, Zhe Xue, Xiaoji Wang, Kai Yuan, Xueling Ge, Yuwen Pan, Chang Liu, Lei Tian, Yuchen Wang, Dongsheng Lu, Boon-Peng Hoh, Shuhua Xu*. PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biology,2019.20:215.
10. Lingxiang Wang#, Yan Lu#, Chao Zhang#, LanHai Wei#, Shi Yan, Yunzhi Huang, Chuanchao Wang, Swapan Mallick, Shaoqing Wen, Li Jin, Shuhua Xu*, Hui Li*. Reconstruction of Y-chromosome phylogeny reveals two neolithic expansions of Tibeto-Burman populations. Molecular Genetics and Genomics, 2018, 293:1293–1300
11. Chao Zhang#, Yan Lu#, Qidi Feng#, Xiaoji Wang#, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang and Shuhua Xu*, Differentiated demographic histories and local adaptations between Sherpas and Tibetans, Genome Biology, 2017, 18:115.
12. Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*, Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia, Molecular Biology and Evolution, 2017, 34(10):2572-2582.
13. Haiyi Lou#,Yan Lu#, Dongsheng Lu#, Ruiqing Fu#, Xiaoji Wang#, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*, A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence, Am.J.Hum.Genet, 2015, 97(1):54-66.
14. Yan Lu#, Shangling Pan#, Shuming Qin, Zhengdong Qin, Chuanchao Wang, Ruijing Gan, Hui Li, the Genographic Consortium, Genetic evidence for the multiple origins of Pinghua Chinese, Journal of Systematics and Evolution, 2013, 51(3):271-279.
15. Yan Lu#, Longli Kang#, Kang Hu, Chuanchao Wang, Xiaoji Sun, Feng Chen, Judith R Kidd, Kenneth K Kidd, Hui Li..High diversity and no significant selection signal of human ADH1B gene in Tibet, Investigative Genetics, 2012, 3:23.
16. Yan Lu, ChuanChao Wang, Zhendong Qin, Bo Wen, Sara E Farina, Li Jin, Hui Li. the Genographic Consortium, Mitochondrial Origin of the Matrilocal Mosuo People in China. Mitochondrial DNA, 2011, 23(1):13-19.
17. Longli Kang#, Yan Lu#, Chuanchao Wang, Kang Hu, Feng Chen, Kai Liu, Shilin Li, Li Jin, Hui Li. the Genographic Consortium, Y-chromosome O3 Haplogroup Diversity in Sino-Tibetan Populations Reveals Two Migration Routes into the Eastern Himalayas, Ann Hum Genet, 2011, 76(1):92-99